Opening the bottle
The screw cap is equipped with an inner pin. By twisting the cap to the right, the inner pin is piercing, and thereby opening the bottle.
Oxovasin solution can be stored at ambient temperature. Once open, the bottles for multiple uses must be securely fastened and stored in a dark place (in the outer carton), otherwise the effectiveness may be lessened.
Contact between the bottle opening and the skin or wound should be avoided. The sterile solution must not be used more than 14 days after opening of the bottle.
How to apply Oxovasin
Oxovasin solution should be applied directly to the wound, either by applying cotton compresses dampened with Oxovasin, or by instillation into fistulas and wound cavities.
How much Oxovasin should be applied – and how often?
Oxovasin is a colorless, aqueous solution. It should be applied twice daily to the wound or wound cavern.
On visually progressive wound healing, the dosage may be reduced to once daily.
The amount to be used depends on the size of the wound. For a wound size of 10cm x 10cm which can be covered by a sterile cotton compress of the same size, 5ml Oxovasin should be sufficient. The overall quantity of the necessary solution depends on the wound size which can be covered by an appropriate number of cotton compresses.
With large wound pockets and caverns, the amount of Oxovasin solution is determined by the number of loosely packed cotton compresses being used.
Between 5–10ml of Oxovasin can be used when instilling fistula systems or deep wound cavities.
How and when should you apply Oxovasin
The recommended method of treatment consists of applying cotton compresses dampened with Oxovasin. Oxovasin solution is compatible with all dressing materials not containing pharmaceutical active ingredients.
If the dressing only needs to be changed once daily, the wound can be moistened by applying Oxovasin to the overlying bandage. With deep wound pockets a cotton compress dampened with Oxovasin solution should be loosely packed into the pocket. This ensures that Oxovasin solution reaches deeper wound regions. All pressure should be avoided as not to damage the new tissue formation (granulation).
Should the application of Oxovasin solution not be possible via an overlying bandage, then the solution can be applied into wound pockets and caverns through existing drainages. Also, the application into fistula systems is possible. Mechanical flushing with saline solution prior to the application of Oxovasin is recommended. In this mode of application, 5-10ml of Oxovasin solution is also sufficient.
How long you should apply Oxovasin
The duration of treatment corresponds with the pre-determined treatment goal. Based on the treatment goal, this can take 3 weeks (e.g., wound healing disturbances) to possibly several months (e.g., lower leg ulcerations).
Special observations during Oxovasin treatment
Side-effects of treatment with Oxovasin solution may be caused by the formation of wound secretion (exudation) preceding the reparative phase of the wound healing. These appearances are predominantly seen in the treatment of venous ulcers in the lower leg and will normalize themselves in due course with treatment.
Reddening the wound edges
The reddening of the surrounding tissue near to the wound at the beginning of the treatment is a sign of improved circulation (hyperemic reaction).
Itching, burning, mild pain
Occasionally at the beginning of treatment, these sensations indicate the start of the wound-healing process. If this occurs, the wound can be remoistened using saline solution. Swelling in the near surroundings of the wound may lead to mild pain. These are also signs of healing (exudative pressure on nerve end fibers).
Wound secretion with venous leg ulcers or decubitus ulcers
In the starting phase of wound healing, an increase in wound secretion may be seen. This can lead to the necessity of repeated bandage changing per day. If after initial wound cleansing, an increased wound smear as well as increased secretion and discoloration of the granulation tissue appear during further treatment, a case of overdosing must be assumed. On reducing the amount of Oxovasin solution being used, a healthy appearance should return. The principal of moistened wound therapy should be maintained in any event (possibly alternating use of Oxovasin/saline solution).
If spontaneous bleeding occurs following the contact with the newly formed granulation tissue, this is a positive sign indicating the development of new capillaries and does not require additional therapeutic measures.
Enlargement of the wound
An apparent increase in wound size at the beginning of treatment may be caused by the disintegration of unviable tissue unable to participate in the regeneration process. Upon Oxovasin therapy, a quick demarcation between healthy and dead tissue is seen.
Use Oxovasin solution only following the instructions described in the package insert. If you have any questions, please consult your doctor or pharmacist.